Current Research Focus

Research in the Davidson Laboratory is focused on inherited genetic diseases that cause central nervous system dysfunction, with a focus on (1) recessive, childhood onset neurodegenerative disease, such as the lysosomal storage diseases mucopolysaccharidoses and Battens disease; (2) dominant genetic diseases, specifically the CAG repeat disorders, Huntington’s disease and spinal cerebellar ataxia; and (3), understanding how changes in the transcriptome impact neural development and neurodegenerative disease processes.

Recent News and Publications

Dr. Beverly DavidsonPublished on November 12th, 2019
Dr. Beverly Davidson elected to National Academy of Medicine
Neuroscientist and Gene Therapy Expert at Children’s Hospital of Philadelphia Receives Outstanding Honor in Medicine
Read more here.

Published on November 13th, 2019
Neuronal network dysfunction precedes storage and neurodegeneration in a lysosomal storage disorder.
Ahrens-Nicklas RC, Tecedor L, Hall AF, Lysenko E, Cohen AS, Davidson BL, Marsh ED.
JCI Insight. 2019 Nov 1. doi: 10.1172/jci.insight.131961 (Abstract)

Published on November 13th, 2019
Standard screening methods underreport AAV-mediated transduction and gene editing.
Lang JF, Toulmin SA, Brida KL, Eisenlohr LC, Davidson BL
Nat Commun, 2019 Jul 30. doi: 10.1038/s41467-019-11321-7. (Full text)

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